FCPS Part 1 Medicine & Allied, Paper 2
Every chapter for the Medicine & Allied Paper 2, in CPSP syllabus order. Paper 1 is the same for every specialty and is in the subject chapters.
Most repeated Paper 2 topicsPractise Medicine questionsMedicine Paper 2 study guideWhole textbook
Paper 2: Anatomy: Embryology: heart, brain and kidney development
- Neural tube defectsNeural tube formation and neural tube defects: spina bifida, anencephaly
- Heart developmentHeart and great vessels development and fetal circulation: FCPS embryology
- Urogenital developmentUrogenital development: kidney, bladder, gonads, genital ducts and anomalies
Paper 2: Anatomy: Histology: liver, pancreas, spleen, kidney, brain, gut
- Muscle and nerve histologyMuscle and nerve tissue: histology of muscle types, neurones and glia
- Gut histologyGut histology from oesophagus to colon; liver, gallbladder and pancreas
- Lung and lymphoid histologyLung, blood vessel and lymphoid organ histology: spleen, thymus, lymph node
- Kidney and endocrine histologyKidney, urinary tract, reproductive, skin and endocrine histology
Paper 2: Anatomy: Regional anatomy for physicians
- Heart and pericardiumHeart and pericardium anatomy: chambers, valves, conduction, coronary arteries
- Limb nerve lesionsUpper and lower limb nerve lesions, roots, pulses and veins (FCPS Part 1)
- Abdomen and pelvis anatomyAbdomen and pelvis anatomy: gut, liver, portal system, kidney, adrenal and bladder
- Head and neck anatomyHead, neck and spine anatomy: cranial nerves, neck, thyroid, cord and lumbar puncture
Paper 2: Anatomy: Central nervous system
- Spinal cord tractsSpinal cord: tracts, blood supply, cord syndromes and Brown-Séquard
- Brainstem anatomyBrainstem: midbrain, pons, medulla, cranial nerve nuclei and brainstem syndromes
- Cranial nervesCranial nerves I–XII: nuclei, exits, functions, reflexes and lesions
- Cerebral cortexCerebral cortex: lobes, Brodmann areas, speech areas and aphasias
- Internal capsule and basal gangliaInternal capsule, basal ganglia and thalamus: anatomy, circuits and lesions
- Cerebellum anatomyCerebellum: functional divisions, cortex, peduncles, connections and lesions
- Ventricles and CSFVentricles, CSF circulation, hydrocephalus, raised pressure and meninges
- Blood supply of the brainBlood supply of the brain: circle of Willis, stroke territories and syndromes
- Visual pathwayVisual pathway: field defects, pupillary reflexes and their lesions
- Autonomic nervous system anatomyAutonomic nervous system: sympathetic and parasympathetic outflow, ganglia and Horner
- Limbic system and hypothalamusLimbic system, hypothalamus and reticular formation: functions and lesions
Paper 2: Physiology and biochemistry: Cardiovascular system
- Cardiac action potentialCardiac muscle, conduction and action potentials
- Cardiac cycleCardiac Cycle, Heart Sounds, JVP and Pressures: FCPS Part 1 Physiology
- Cardiac outputCardiac Output, Venous Return and the Frank–Starling Law: FCPS Part 1
- ECG and arrhythmiasECG, Arrhythmias and Heart Block: FCPS Part 1 Physiology Guide
- Blood pressure regulationArterial Pressure and Its Regulation: Baroreflex, RAAS, Kidney (FCPS Part 1)
- Starling forces and oedemaMicrocirculation, Starling Forces, Oedema and Lymph: FCPS Part 1 Physiology
- Regional circulationsRegional circulations: coronary, cerebral, pulmonary, skin and muscle blood flow
- Shock and heart failureShock and heart failure: types, compensation after haemorrhage and HF physiology
Paper 2: Physiology and biochemistry: Respiratory system
- Lung volumes and spirometryLung volumes, capacities, dead space and pulmonary function tests (spirometry)
- Mechanics of breathingMechanics of breathing: compliance, surfactant, pleural pressure and airway resistance
- Ventilation-perfusion ratioVentilation–perfusion (V/Q), diffusion, shunt and gas exchange in the lung
- Oxygen dissociation curveOxygen and carbon dioxide transport; the dissociation curve
- Control of breathingControl of breathing: chemoreceptors, hypoxia, cyanosis, altitude and oxygen therapy
Paper 2: Physiology and biochemistry: Gastrointestinal system and liver
- Gastrointestinal motilityGI motility: swallowing, gastric emptying, peristalsis, vomiting and defecation
- Gastrointestinal secretionsSalivary, gastric, pancreatic and biliary secretion: cells, control and composition
- Gastrointestinal hormonesGI hormones: gastrin, secretin, CCK, GIP, GLP-1, motilin and somatostatin
- Digestion and absorptionDigestion and absorption: carbohydrate, protein, fat, water, iron, B12 and calcium
- Liver functions and bilirubinLiver functions, bilirubin metabolism, jaundice and liver failure
Paper 2: Physiology and biochemistry: Renal physiology, body fluids and acid-base
- Body fluid compartmentsBody fluid compartments: volumes, markers, osmolality and fluid shifts
- GFR and renal clearanceGFR, renal blood flow, autoregulation and renal clearance (with worked calculations)
- Tubular reabsorption and secretionTubular reabsorption and secretion: what each nephron segment does, diuretics and Tm
- Countercurrent mechanismUrine concentration: countercurrent multiplier, ADH, diabetes insipidus and SIADH
- Renal electrolyte handlingSodium, potassium, calcium, phosphate and magnesium handling by the kidney
- Acid-base balanceAcid–base balance: buffers, ABG interpretation, anion gap, RTA and mixed disorders
- Micturition reflexMicturition and bladder function: nerve supply, reflex centres and neurogenic bladder
Paper 2: Physiology and biochemistry: Nervous system
- Somatosensory pathways and painSensory receptors, somatosensory pathways, pain physiology and referred pain
- Motor systemMotor system: motor cortex, corticospinal tract, extrapyramidal tracts, UMN vs LMN
- Spinal reflexesSpinal reflexes, muscle spindle, Golgi tendon organ, spinal shock, clonus and posture
- Cerebellum and basal gangliaCerebellum and basal ganglia: cerebellar signs, Parkinson disease, chorea and tremor
- Sleep, memory and speechHigher functions: sleep stages, EEG, memory, speech areas, limbic system and hypothalamus
- Autonomic nervous systemAutonomic nervous system: sympathetic, parasympathetic, receptors and transmitters
- Temperature regulationTemperature regulation, fever, heat illness and hypothermia
Paper 2: Physiology and biochemistry: Special senses
- Physiology of visionVision: optics, retina, rods and cones, colour vision, accommodation and pupil reflexes
- Hearing and balanceHearing and balance: middle ear, cochlea, hair cells, hearing tests and vestibular system
- Smell and tasteSmell and taste: olfactory pathway, taste buds, taste nerves and disorders
Paper 2: Physiology and biochemistry: Endocrinology
- Pituitary hormonesHormone mechanisms, feedback, hypothalamus and pituitary: GH, prolactin, ADH, oxytocin
- Thyroid hormonesThyroid hormones: synthesis, actions, thyroid function tests, hypo- and hyperthyroidism
- Adrenal hormonesAdrenal cortex and medulla: cortisol, aldosterone, CAH, Cushing and Addison disease
- Insulin and glucagonEndocrine pancreas: insulin release, insulin and glucagon actions, diabetes, DKA and HHS
- Calcium and bone physiologyCalcium and bone: PTH, vitamin D, calcitonin, hyper- and hypocalcaemia, bone drugs
Paper 2: Physiology and biochemistry: Reproduction
- Male reproductive physiologyMale reproductive physiology: spermatogenesis, testosterone, semen and male infertility
- Female reproductive physiologyFemale reproductive physiology: menstrual cycle, ovulation, puberty and menopause
- Pregnancy physiologyPregnancy physiology: placental hormones, maternal changes, labour and lactation
- Fetal and neonatal physiologyFetal and neonatal physiology: fetal circulation, HbF, surfactant and newborn adaptation
Paper 2: Pharmacology: Systemic drugs
- Adrenergic drugsAdrenergic Agonists, Beta-Blockers, Inotropes and Vasopressors: FCPS Part 1
- Antiepileptics and sedativesSedatives, Antiepileptics and Antiparkinson Drugs: FCPS Part 1 Pharmacology
- Analgesics and NSAIDsOpioids, NSAIDs, Paracetamol, DMARDs, Gout and Migraine Drugs: FCPS Part 1
- Antiarrhythmic and antianginal drugsAntianginal, Heart Failure and Antiarrhythmic Drugs: FCPS Part 1 Pharmacology
- Lipid-lowering drugsLipid-Lowering Drugs: Statins, Ezetimibe, PCSK9, Fibrates for FCPS Part 1
- Anticoagulants and antiplateletsAntiplatelets, Anticoagulants, Thrombolytics and Haematinics: FCPS Part 1
- Gastrointestinal drugsAcid-Peptic, Antiemetic, Laxative, IBD and Motility Drugs: FCPS Part 1
- Asthma drugs and antihistaminesAsthma and COPD Drugs, Antihistamines and Corticosteroids: FCPS Part 1
- Antidiabetic drugsAntidiabetic Drugs and Insulins: Mechanisms and Side Effects for FCPS Part 1
- Endocrine drugsThyroid, Corticosteroid, Sex Hormone and Bone Drugs: FCPS Part 1 Pharmacology
- Vaccines and infection controlVaccines, immunoglobulins and hospital infection control for FCPS
Paper 2: Pharmacology: Antimicrobials
- Antibacterial drugsAntibacterial Drugs: Mechanisms, Resistance, Toxicity, Surgical Prophylaxis (FCPS Part 1)
- Antituberculous drugsAntituberculous and Antileprosy Drugs: Regimens and Toxicity for FCPS Part 1
- Antivirals and antifungalsAntivirals, Antifungals, Antimalarials, Antiprotozoals and Anthelmintics: FCPS Part 1
Paper 2: Pathology, microbiology and immunology: Neoplasia and genetics
- Neoplasia and carcinogenesisNeoplasia for FCPS: carcinogenesis, oncogenes, spread, grading, staging and markers
- Genetic disordersGenetic disorders: inheritance patterns, risk calculation and chromosomal syndromes
- Environmental pathologyEnvironmental pathology: smoking, alcohol, occupational dusts, toxins, radiation
- Atherosclerosis and aneurysmsAtherosclerosis, ischaemic heart disease, limb ischaemia and aneurysms for FCPS
Paper 2: Pathology, microbiology and immunology: Immunopathology
- Basic immunologyImmunology for FCPS Part 1: innate and adaptive immunity, autoimmunity, transplants
- Hypersensitivity reactionsHypersensitivity reactions types I to IV for FCPS: mechanisms and examples
- Immunodeficiency and HIVImmunodeficiency Disorders and HIV: Primary, Secondary and Opportunistic Infections
- Transplant immunologyTransplant immunology, immunosuppressants, HLA and amyloidosis for FCPS
Paper 2: Pathology, microbiology and immunology: Infectious diseases
- Viral infectionsVirology for FCPS: HIV, rabies, herpesviruses, influenza, hepatitis and HPV
- Viral hepatitisViral Hepatitis A to E: Serology, Pathology, Treatment and Needlestick Injury
- Parasitic infectionsParasitology for FCPS: malaria, leishmania, amoebiasis, worms and hydatid cyst
- Tuberculosis and leprosyTuberculosis and Leprosy: Pathogenesis, Sites, Diagnosis, Drugs and Surgery
- Bacterial infectionsBacterial infections for FCPS: typhoid, cholera, meningitis, pneumonia, endocarditis
Paper 2: Pathology, microbiology and immunology: Haematopoietic and lymphoid disorders
- Anaemia and haemolysisAnaemia, thalassaemia, sickle cell and haemolysis for FCPS: red cell disorders
- Leukaemia and lymphomaLeukaemia, Lymphoma, Myeloma, Myeloproliferative Neoplasms and the Spleen
- Bleeding disorders and transfusionBleeding disorders, DIC, anticoagulant reversal and blood transfusion for FCPS
- White cell disordersWhite cell disorders for FCPS: neutrophilia, neutropenia, lymphocytosis and eosinophilia