Tranexamic acid
Trauma and PPH: 1 g IV over 10 minutes within 3 hours. Trauma: then 1 g over 8 hours. PPH: second 1 g if bleeding continues after 30 minutes.
On this page
Dose
| Indication | Dose |
|---|---|
| Major trauma (within 3 hours) | 1 g IV over 10 minutes, then 1 g IV over 8 hours |
| PPH (within 3 hours of birth) | 1 g IV over 10 minutes; second 1 g if bleeding continues after 30 minutes or restarts within 24 hours |
| Head injury, mild–moderate (within 3 hours) | 1 g IV over 10 minutes, then 1 g over 8 hours |
| Epistaxis, menorrhagia | 1 g orally 3 times daily |
| Child (trauma) | 15 mg/kg (max 1 g) IV, then 2 mg/kg/hour |
Cautions
- Less effective and possibly harmful after 3 hours in trauma.
- Avoid in upper urinary tract bleeding (clot colic) and active thrombosis.
Frequently asked questions
When should tranexamic acid be given in trauma?
Within 3 hours of injury; benefit falls with every 15 minutes of delay.
Used in these guides
Sources
Doses on this page are typical doses from the sources above. Always confirm with a current drug reference, the product leaflet and your hospital protocol, especially in children, pregnancy and kidney or liver disease.