Clopidogrel

A P2Y12 antiplatelet. 300–600 mg loading in ACS, then 75 mg daily.

P2Y12 antiplateletReviewed October 2026

Common brands in Pakistan: Plavix, Lowplat. Brand availability changes; check with your pharmacy.

On this page

Dose

IndicationDose
ACS300–600 mg loading dose, then 75 mg daily (usually 12 months with aspirin)
With thrombolysis300 mg (75 mg if over 75 years), then 75 mg daily
Stroke or peripheral arterial disease75 mg daily

Cautions

  • Bleeding; stop 5–7 days before most surgery (discuss with cardiology if stented).
  • Omeprazole and esomeprazole reduce its effect: prefer pantoprazole.

Frequently asked questions

What is the loading dose of clopidogrel?

300–600 mg, depending on the indication and protocol.

Used in these guides

Sources

  1. Drugs.com: Clopidogrel dosage

Doses on this page are typical doses from the sources above. Always confirm with a current drug reference, the product leaflet and your hospital protocol, especially in children, pregnancy and kidney or liver disease.

For FCPS Part 1

Revising for FCPS Part 1? Clopidogrel is covered in our textbook chapter Anticoagulants and antiplatelets, with practice MCQs.