Alteplase
Thrombolysis. Stroke: 0.9 mg/kg (max 90 mg), 10% as a bolus. Massive PE: 100 mg over 2 hours (or 50 mg bolus in arrest).
On this page
Dose
| Indication | Dose |
|---|---|
| Acute ischaemic stroke | 0.9 mg/kg (max 90 mg): 10% IV bolus over 1 minute, rest over 60 minutes |
| Massive PE | 100 mg IV over 2 hours (10 mg bolus then 90 mg over 2 hours); in cardiac arrest, 50 mg bolus |
| STEMI (accelerated regimen) | 15 mg bolus, 0.75 mg/kg over 30 minutes (max 50 mg), then 0.5 mg/kg over 60 minutes (max 35 mg) |
Cautions
- Senior decision. Check contraindications: recent bleeding, stroke, surgery, trauma, uncontrolled BP, aortic dissection.
- BP must be below 185/110 before stroke thrombolysis.
Frequently asked questions
What is the alteplase dose in stroke?
0.9 mg/kg up to 90 mg, with 10% as a bolus and the rest over an hour.
Used in these guides
Sources
Doses on this page are typical doses from the sources above. Always confirm with a current drug reference, the product leaflet and your hospital protocol, especially in children, pregnancy and kidney or liver disease.