Ticagrelor
A P2Y12 antiplatelet for ACS: 180 mg loading, then 90 mg twice daily with aspirin.
On this page
Dose
180 mg loading dose, then 90 mg twice daily with low-dose aspirin (75 mg), usually for 12 months.
Cautions
- Bleeding; avoid with previous intracranial bleed.
- Breathlessness and slow pulse are common side effects.
- Aspirin above 100 mg a day reduces its effect.
- Interacts with strong CYP3A4 inhibitors (clarithromycin).
Frequently asked questions
Why does ticagrelor cause breathlessness?
It is a known side effect, usually mild and settling, but significant breathlessness needs review.
Used in these guides
Sources
Doses on this page are typical doses from the sources above. Always confirm with a current drug reference, the product leaflet and your hospital protocol, especially in children, pregnancy and kidney or liver disease.
For FCPS Part 1
Revising for FCPS Part 1? Ticagrelor is covered in our textbook chapter Anticoagulants and antiplatelets, with practice MCQs.