Streptokinase
1.5 million units IV over 60 minutes for STEMI. Still widely used in Pakistan; don't repeat after previous exposure.
On this page
Dose
1.5 million units IV in 100 mL of 0.9% saline over 60 minutes, with aspirin and clopidogrel.
Cautions
- Low BP during infusion (slow or pause), allergic reactions.
- Antibodies form: don't repeat streptokinase after previous use (from 5 days to years after); use a different thrombolytic.
- Same contraindications as other thrombolytics.
Frequently asked questions
Can streptokinase be given twice?
No. Antibodies make a repeat dose less effective and risk allergic reactions.
Used in these guides
Sources
Doses on this page are typical doses from the sources above. Always confirm with a current drug reference, the product leaflet and your hospital protocol, especially in children, pregnancy and kidney or liver disease.
For FCPS Part 1
Revising for FCPS Part 1? Streptokinase is covered in our textbook chapter Anticoagulants and antiplatelets, with practice MCQs.