Pregabalin
For neuropathic pain. Start 75 mg twice daily and increase; reduce in kidney disease. Misuse potential.
On this page
Dose
Start 75 mg twice daily (25–50 mg in the elderly), increase after 3–7 days to 150 mg twice daily, max 300 mg twice daily.
Kidney
| Creatinine clearance (mL/min) | Total daily dose |
|---|---|
| 30–60 | 75–300 mg |
| 15–30 | 25–150 mg |
| Below 15 | 25–75 mg |
Cautions
- Dizziness, drowsiness, weight gain, swelling.
- Breathing depression with opioids; misuse and dependence.
- NICE advises against gabapentinoids for low back pain.
Frequently asked questions
Does pregabalin help back pain?
NICE advises against pregabalin for low back pain without nerve pain.
Used in these guides
Sources
Doses on this page are typical doses from the sources above. Always confirm with a current drug reference, the product leaflet and your hospital protocol, especially in children, pregnancy and kidney or liver disease.