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Home / Physiology / Excitable Tissue

Excitable Tissue

4 topics in Excitable Tissue for PGET Paper I Physiology. Each one explains the concept simply, then gives exam-focus points and a quick revision list.

Membrane potential and ion channelsWhy the inside of a cell is negative at rest, how equilibrium potentials are worked out, the role of the sodium-potassium pump, and the types of ion channel (leak, voltage-gated, ligand-gated and NMDA).The nerve action potentialThe phases of the action potential and the ion channels behind each, threshold and the all-or-none law, refractory periods, how fast impulses travel, and how potassium and calcium changes alter excitability.Synaptic transmissionHow signals pass from one neuron to the next at chemical and electrical synapses, how excitatory and inhibitory potentials add up, the main neurotransmitters, and the special properties of synapses.The neuromuscular junctionHow a motor nerve makes a skeletal muscle fibre contract, the end-plate potential, how acetylcholine is removed, and how drugs, toxins and diseases such as myasthenia gravis interfere with transmission.
Previous chapterNeurophysiologyNext chapterCardiovascular Physiology

All Physiology chapters · All PGET subjects

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For education and revision. Not a medical device and not a substitute for clinical judgement, senior advice or your hospital’s protocols. Check every dose against a current drug reference before prescribing. Not affiliated with PMDC, CPSP, NUMS or any hospital.