Phenoxymethylpenicillin (penicillin V)
The first-choice antibiotic for strep tonsillitis. A full 10-day course helps prevent rheumatic fever.
On this page
Uses
- Streptococcal tonsillitis and pharyngitis.
- Mild cellulitis or erysipelas.
- Secondary prevention of rheumatic fever (oral alternative to benzathine penicillin).
Adult dose
| Indication | Dose |
|---|---|
| Tonsillitis | 500 mg 4 times daily or 1 g twice daily for 10 days (5 days in some UK guidance) |
| Rheumatic fever prophylaxis | 250 mg twice daily |
Children's dose
| Age | Dose (4 times daily) |
|---|---|
| 1–5 years | 125 mg |
| 6–11 years | 250 mg |
| 12 years and over | 500 mg |
Kidney and liver
Reduce in severe kidney impairment.
Pregnancy and breastfeeding
Safe.
Side effects and cautions
- Take on an empty stomach.
- Penicillin allergy: avoid.
Frequently asked questions
How long should strep throat be treated?
10 days of penicillin V is traditionally recommended to prevent rheumatic fever.
Used in these guides
Sources
Doses on this page are typical doses from the sources above. Always confirm with a current drug reference, the product leaflet and your hospital protocol, especially in children, pregnancy and kidney or liver disease.