Noradrenaline (norepinephrine)
The first-choice vasopressor in septic shock, given by infusion and titrated to MAP 65 mmHg or more.
On this page
Dose
Start at 0.05–0.1 micrograms/kg/minute and titrate to a MAP of 65 mmHg or more (typical range 0.05–1 micrograms/kg/minute), ideally through a central line with arterial BP monitoring (ICU/HDU).
Cautions
- Can be started peripherally through a large, well-placed cannula for a short time while central access is arranged (per local protocol); watch for extravasation.
- Correct hypovolaemia first.
Frequently asked questions
What MAP target is used with noradrenaline?
Usually 65 mmHg or more.
Used in these guides
Sources
Doses on this page are typical doses from the sources above. Always confirm with a current drug reference, the product leaflet and your hospital protocol, especially in children, pregnancy and kidney or liver disease.
For FCPS Part 1
Revising for FCPS Part 1? Noradrenaline is covered in our textbook chapter Adrenergic drugs, with practice MCQs.