Fosfomycin

A single 3 g sachet treats uncomplicated cystitis in women, useful for resistant organisms.

Phosphonic acid antibioticReviewed October 2026
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Uses

  • Uncomplicated cystitis in women, including resistant (ESBL) organisms.

Adult dose

IndicationDose
Cystitis, women3 g single dose dissolved in water, taken on an empty stomach (often at bedtime after emptying the bladder)
Cystitis, men (specialist or culture-guided)3 g, repeated after 72 hours

Kidney and liver

Avoid if creatinine clearance below 10.

Pregnancy and breastfeeding

Considered acceptable when needed.

Side effects and cautions

  • Diarrhoea, nausea, headache.

Frequently asked questions

How is fosfomycin taken?

Dissolve the 3 g sachet in water and drink it on an empty stomach, ideally at bedtime after emptying the bladder.

Does fosfomycin work for pyelonephritis?

The oral sachet is not suitable for pyelonephritis.

Used in these guides

Sources

  1. Drugs.com: Fosfomycin dosage

Doses on this page are typical doses from the sources above. Always confirm with a current drug reference, the product leaflet and your hospital protocol, especially in children, pregnancy and kidney or liver disease.