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Home / Biochemistry / Energy Metabolism

Energy Metabolism

3 topics in Energy Metabolism for PGET Paper I Biochemistry. Each one explains the concept simply, then gives exam-focus points and a quick revision list.

Glycolysis, Krebs cycle and the electron transport chainHow cells extract energy from glucose: glycolysis and its control, pyruvate dehydrogenase, the Krebs (TCA) cycle, the electron transport chain and oxidative phosphorylation with their inhibitors and uncouplers, then gluconeogenesis, glycogen metabolism, the pentose phosphate pathway and the key enzyme defects, with ATP yields worked out by hand.Fatty acids, lipoproteins and cholesterolHow fats are digested and carried (micelles, chylomicrons and the other lipoproteins), how fatty acids are made and burned (acetyl-CoA carboxylase, carnitine shuttle, beta-oxidation), how cholesterol is made and controlled (HMG-CoA reductase, LDL receptors), the hyperlipoproteinaemias and lipid storage diseases, and the ATP yield of palmitate worked out by hand.Ketone bodies, fed and fasting states and fatty liverHow the body switches fuels between meals: the fed (absorptive) state under insulin, the fasting state under glucagon, prolonged starvation, ketone body formation and use, diabetic and alcoholic ketoacidosis, the metabolic differences between type 1 and type 2 diabetes, and why fat builds up in the liver.
Previous chapterHormones and Signal Transduction

All Biochemistry chapters · All PGET subjects

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For education and revision. Not a medical device and not a substitute for clinical judgement, senior advice or your hospital’s protocols. Check every dose against a current drug reference before prescribing. Not affiliated with PMDC, CPSP, NUMS or any hospital.