Phenytoin

20 mg/kg IV no faster than 50 mg/minute, with ECG and BP monitoring.

AntiepilepticReviewed October 2026
On this page

Dose

20 mg/kg IV in 0.9% saline at no more than 50 mg/minute (1 mg/kg/minute in children, max 50 mg/minute), then maintenance by levels.

Cautions

  • ECG and BP monitoring: bradycardia, heart block, low BP.
  • Tissue damage if it leaks ("purple glove").
  • Many interactions (warfarin, OCP, others).
  • Toxicity: nystagmus, ataxia, slurred speech.

Frequently asked questions

How fast can phenytoin be infused?

No faster than 50 mg per minute in adults.

Used in these guides

Sources

  1. Drugs.com: Phenytoin dosage

Doses on this page are typical doses from the sources above. Always confirm with a current drug reference, the product leaflet and your hospital protocol, especially in children, pregnancy and kidney or liver disease.

For FCPS Part 1

Revising for FCPS Part 1? Phenytoin is covered in our textbook chapter Pharmacokinetics and half-life, with practice MCQs.